Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
5ht2c_human | 172 | 4.43x43 | TM4 | I => Ter | stop gained | 1.176e-05 | 1 | 85009 | 0 | None | None | |
5ht2c_human | 179 | 4.50x50 | TM4 | W => Ter | stop gained | 1.151e-05 | 1 | 86912 | 0 | None | None | |
5ht2c_human | 222 | 5.46x461 | TM5 | A => Ter | stop gained | 3.42e-05 | 3 | 87714 | 0 | None | None | LB (Van der Waals, hydrophobic) |
5ht2c_human | 238 | 5.62x62 | TM5 | I => Ter | stop gained | 1.14e-05 | 1 | 87726 | 0 | None | None | |
5ht2c_human | 425 | C-term | E => Ter | stop gained | 1.14e-05 | 1 | 87693 | 0 | None | None | ||
5ht2c_human | 3 | N-term | N => S | missense | 0.000105 | 6 | 57125 | 0 | nan | 0.899 | ||
5ht2c_human | 7 | N-term | A => V | missense | 0.0003345 | 19 | 56802 | 0 | nan | 0.004 | ||
5ht2c_human | 7 | N-term | A => E | missense | 1.761e-05 | 1 | 56802 | 0 | nan | 0.333 | ||
5ht2c_human | 9 | N-term | H => R | missense | 1.768e-05 | 1 | 56551 | 0 | nan | 0.001 | ||
5ht2c_human | 11 | N-term | F => L | missense | 1.796e-05 | 1 | 55676 | 0 | nan | 0.001 | ||
5ht2c_human | 12 | N-term | L => F | missense | 1.8e-05 | 1 | 55559 | 0 | nan | 0.766 | ||
5ht2c_human | 13 | N-term | V => A | missense | 1.185e-05 | 1 | 84369 | 0 | nan | 0.122 | ||
5ht2c_human | 16 | N-term | I => T | missense | 2.356e-05 | 2 | 84898 | 0 | nan | 0.541 | ||
5ht2c_human | 17 | N-term | G => V | missense | 1.176e-05 | 1 | 85032 | 0 | nan | 0.471 | ||
5ht2c_human | 23 | N-term | S => S | missense | 0.1544 | 13292 | 86103 | 847 | nan | 0.005 | ||
5ht2c_human | 25 | N-term | I => V | missense | 2.318e-05 | 2 | 86298 | 0 | nan | 0.01 | ||
5ht2c_human | 30 | N-term | V => A | missense | 1.149e-05 | 1 | 87015 | 0 | nan | 0.015 | ||
5ht2c_human | 31 | N-term | A => T | missense | 1.148e-05 | 1 | 87094 | 0 | nan | 0.015 | ||
5ht2c_human | 31 | N-term | A => V | missense | 1.148e-05 | 1 | 87129 | 0 | nan | 0.095 | ||
5ht2c_human | 33 | N-term | I => T | missense | 1.145e-05 | 1 | 87356 | 0 | nan | 0.002 | ||
5ht2c_human | 33 | N-term | I => M | missense | 4.578e-05 | 4 | 87371 | 0 | nan | 0.002 | ||
5ht2c_human | 42 | N-term | D => H | missense | 0.0002849 | 25 | 87738 | 0 | nan | 0.718 | ||
5ht2c_human | 43 | N-term | G => C | missense | 1.14e-05 | 1 | 87739 | 0 | nan | 0.758 | ||
5ht2c_human | 46 | N-term | F => S | missense | 1.14e-05 | 1 | 87742 | 0 | nan | 0.013 | ||
5ht2c_human | 47 | N-term | K => E | missense | 3.419e-05 | 3 | 87748 | 0 | nan | 0.009 | ||
5ht2c_human | 52 | N-term | V => L | missense | 1.14e-05 | 1 | 87750 | 0 | nan | 0.221 | ||
5ht2c_human | 59 | 1.38x38 | TM1 | S => P | missense | 1.14e-05 | 1 | 87756 | 0 | nan | 0.005 | |
5ht2c_human | 61 | 1.40x40 | TM1 | V => I | missense | 0.0001254 | 11 | 87754 | 0 | nan | 0.03 | |
5ht2c_human | 62 | 1.41x41 | TM1 | I => T | missense | 1.14e-05 | 1 | 87755 | 0 | nan | 0.011 | |
5ht2c_human | 63 | 1.42x42 | TM1 | I => V | missense | 1.14e-05 | 1 | 87755 | 0 | nan | 0.034 | |
5ht2c_human | 79 | 1.58x58 | TM1 | S => R | missense | 2.279e-05 | 2 | 87741 | 0 | nan | 0.771 | |
5ht2c_human | 103 | 2.54x54 | TM2 | G => R | missense | 1.158e-05 | 1 | 86361 | 0 | nan | 0.993 | |
5ht2c_human | 114 | 2.65x64 | TM2 | I => V | missense | 1.188e-05 | 1 | 84169 | 0 | nan | 0.173 | |
5ht2c_human | 117 | 2.68x67 | TM2 | D => G | missense | 1.168e-05 | 1 | 85585 | 0 | nan | 0.048 | |
5ht2c_human | 119 | 23.49x49 | ECL1 | V => I | missense | 1.166e-05 | 1 | 85763 | 0 | nan | 0.18 | |
5ht2c_human | 119 | 23.49x49 | ECL1 | V => D | missense | 1.166e-05 | 1 | 85794 | 0 | nan | 0.055 | |
5ht2c_human | 129 | 3.27x27 | TM3 | V => I | missense | 1.145e-05 | 1 | 87325 | 0 | nan | 0.131 | |
5ht2c_human | 159 | 34.50x50 | ICL2 | P => S | missense | 1.142e-05 | 1 | 87583 | 0 | nan | 0.982 | GP (contact) |
5ht2c_human | 160 | 34.51x51 | ICL2 | I => V | missense | 1.142e-05 | 1 | 87578 | 0 | nan | 0.042 | GP (contact) |
5ht2c_human | 166 | 34.57x57 | ICL2 | N => S | missense | 2.285e-05 | 2 | 87511 | 0 | nan | 0.42 | GP (contact) |
5ht2c_human | 168 | 4.39x39 | TM4 | R => Q | missense | 3.429e-05 | 3 | 87479 | 0 | nan | 0.928 | |
5ht2c_human | 171 | 4.42x42 | TM4 | A => V | missense | 0.0005493 | 48 | 87385 | 0 | nan | 0.402 | |
5ht2c_human | 172 | 4.43x43 | TM4 | I => V | missense | 9.16e-05 | 8 | 87332 | 0 | nan | 0.105 | |
5ht2c_human | 217 | 5.41x42 | TM5 | I => T | missense | 2.282e-05 | 2 | 87624 | 0 | nan | 0.367 | |
5ht2c_human | 269 | ICL3 | R => K | missense | 1.14e-05 | 1 | 87719 | 0 | nan | 0.001 | ||
5ht2c_human | 280 | ICL3 | P => L | missense | 2.279e-05 | 2 | 87740 | 0 | nan | 0.043 | ||
5ht2c_human | 282 | ICL3 | Q => H | missense | 2.279e-05 | 2 | 87743 | 0 | nan | 0.001 | ||
5ht2c_human | 283 | ICL3 | D => Y | missense | 1.14e-05 | 1 | 87739 | 0 | nan | 0.696 | ||
5ht2c_human | 287 | ICL3 | R => C | missense | 1.14e-05 | 1 | 87731 | 0 | nan | 0.001 | ||
5ht2c_human | 287 | ICL3 | R => H | missense | 1.14e-05 | 1 | 87726 | 0 | nan | 0.008 | ||
5ht2c_human | 288 | ICL3 | R => Q | missense | 1.141e-05 | 1 | 87674 | 0 | nan | 0.006 | ||
5ht2c_human | 289 | ICL3 | R => K | missense | 1.141e-05 | 1 | 87665 | 0 | nan | 0.003 | ||
5ht2c_human | 294 | ICL3 | R => K | missense | 2.28e-05 | 2 | 87723 | 0 | nan | 0.0 | ||
5ht2c_human | 295 | ICL3 | R => G | missense | 7.98e-05 | 7 | 87718 | 0 | nan | 0.018 | ||
5ht2c_human | 295 | ICL3 | R => C | missense | 1.14e-05 | 1 | 87718 | 0 | nan | 0.157 | ||
5ht2c_human | 300 | 6.24x24 | TM6 | M => I | missense | 1.14e-05 | 1 | 87729 | 0 | nan | 0.27 | |
5ht2c_human | 304 | 6.28x28 | TM6 | N => S | missense | 1.14e-05 | 1 | 87729 | 0 | nan | 0.055 | GP (contact) |
5ht2c_human | 305 | 6.29x29 | TM6 | N => D | missense | 1.14e-05 | 1 | 87734 | 0 | nan | 0.823 | GP (contact) |
5ht2c_human | 314 | 6.38x38 | TM6 | G => R | missense | 1.14e-05 | 1 | 87734 | 0 | nan | 1.0 | |
5ht2c_human | 323 | 6.47x47 | TM6 | M => T | missense | 1.14e-05 | 1 | 87742 | 0 | nan | 0.42 | |
5ht2c_human | 329 | 6.53x53 | TM6 | I => V | missense | 1.14e-05 | 1 | 87746 | 0 | nan | 0.177 | |
5ht2c_human | 337 | 6.61x61 | TM6 | C => F | missense | 1.14e-05 | 1 | 87737 | 0 | nan | 0.999 | |
5ht2c_human | 337 | 6.61x61 | TM6 | C => Y | missense | 1.14e-05 | 1 | 87737 | 0 | nan | 0.999 | |
5ht2c_human | 344 | 7.29x28 | TM7 | K => Q | missense | 1.14e-05 | 1 | 87726 | 0 | nan | 0.01 | |
5ht2c_human | 352 | 7.37x36 | TM7 | V => L | missense | 1.14e-05 | 1 | 87713 | 0 | nan | 0.267 | |
5ht2c_human | 356 | 7.41x40 | TM7 | I => S | missense | 1.14e-05 | 1 | 87696 | 0 | nan | 0.944 | |
5ht2c_human | 372 | 8.47x47 | H8 | N => S | missense | 1.141e-05 | 1 | 87662 | 0 | nan | 0.925 | GP (contact) |
5ht2c_human | 373 | 8.48x48 | H8 | K => N | missense | 1.141e-05 | 1 | 87662 | 0 | nan | 0.666 | GP (contact) |
5ht2c_human | 374 | 8.49x49 | H8 | I => L | missense | 0.000308 | 27 | 87664 | 0 | nan | 0.004 | GP (contact) |
5ht2c_human | 376 | 8.51x51 | H8 | R => Q | missense | 1.141e-05 | 1 | 87648 | 0 | nan | 0.996 | GP (contact) |
5ht2c_human | 384 | 8.59x59 | H8 | R => H | missense | 1.141e-05 | 1 | 87609 | 0 | nan | 0.112 | |
5ht2c_human | 384 | 8.59x59 | H8 | R => L | missense | 1.141e-05 | 1 | 87609 | 0 | nan | 0.142 | |
5ht2c_human | 389 | C-term | V => A | missense | 6.85e-05 | 6 | 87596 | 0 | nan | 0.0 | ||
5ht2c_human | 395 | C-term | V => G | missense | 1.142e-05 | 1 | 87595 | 0 | nan | 0.001 | ||
5ht2c_human | 400 | C-term | R => K | missense | 1.142e-05 | 1 | 87591 | 0 | nan | 0.148 | ||
5ht2c_human | 401 | C-term | V => A | missense | 3.425e-05 | 3 | 87604 | 0 | nan | 0.001 | ||
5ht2c_human | 409 | C-term | R => K | missense | 6.846e-05 | 6 | 87639 | 0 | nan | 0.004 | ||
5ht2c_human | 415 | C-term | I => N | missense | 1.141e-05 | 1 | 87651 | 0 | nan | 0.001 | ||
5ht2c_human | 419 | C-term | T => A | missense | 0.0008326 | 73 | 87675 | 0 | nan | 0.013 | ||
5ht2c_human | 430 | C-term | N => S | missense | 1.14e-05 | 1 | 87711 | 0 | nan | 0.0 | ||
5ht2c_human | 431 | C-term | E => K | missense | 1.14e-05 | 1 | 87715 | 0 | nan | 0.621 | ||
5ht2c_human | 433 | C-term | G => A | missense | 1.14e-05 | 1 | 87709 | 0 | nan | 0.006 | ||
5ht2c_human | 434 | C-term | I => T | missense | 3.421e-05 | 3 | 87704 | 0 | nan | 0.573 | ||
5ht2c_human | 438 | C-term | V => L | missense | 1.14e-05 | 1 | 87681 | 0 | nan | 0.006 | ||
5ht2c_human | 442 | C-term | E => G | missense | 1.142e-05 | 1 | 87551 | 0 | nan | 0.343 | ||
5ht2c_human | 454 | C-term | R => M | missense | 1.154e-05 | 1 | 86648 | 0 | nan | 0.928 | ||
5ht2c_human | 455 | C-term | I => N | missense | 1.156e-05 | 1 | 86542 | 0 | nan | 0.573 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue